| Reportno. |
AHRI report No.36
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| Topic |
Efficacy Evaluations of the Inactivated Swine Vesicular Disease Vaccine
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| Department |
National Institute for Animal Health, Council of Agriculture, Executive Yuan
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| Author |
Ting, Lu- Jen , T. F. Chiou, M. H. Jong and C. Chen |
| Summary |
Swine vesicular disease (SVD) virus, TN1 strain, was grown in ESK cells and reaching a titer of 108.1 TCID50/ml. The SVD water/oil/water (W/O/W) vaccine was prepared from the virus inactivated with binary ethylenimine (BEI) and emulsified with Montanide ISA206. Ten specific pathogen free (SPF) pigs at 5-7 weeks of age were used to evaluate the inactivated SVD vaccine. Results revealed that the SVD vaccine elicited good titers of neutralizing antibodies ranging from 3.79 to 3.88 log10 after two time vaccinations with a four-week interval. This vaccine also conferred protection for pigs post challenge, however the control pigs without receiving vaccination developed visible lesions on the snout, foot and dewclaw areas.
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| Keyword |
Swine vesicular disease, Inactivated vaccine, Water/oil/water vaccine,pecific pathogen free pigs
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