| Summary |
For understanding of preservatives, formaldehyde and thimersol, in the inactivated vaccines or residual moisture in the live vaccines, totally 427 samples for statutory assay of poultry vaccines sold in Taiwan, including the imported and the domestic, were examined during April 2005 and March 2006. Poultry vaccine samples were consisted of monovalent or multivalent vaccines against Newcastle disease, infectious bronchitis, infectious bursal disease, infectious coryza or egg drop syndrome. Significance difference of results among manufacturers or between the imported and the domestic were tested by analysis of variance. In terms of preservatives used in inactivated vaccines, the results of the amount of formaldehyde in 227 samples from 17 manufacturers showed significant difference by manufacturer (p < 0.01). In addition, up to 83.33% of domestic inactivated vaccines and only 9.09% of the imported were tested containing formaldehyde in amount over 0.1%. This indicated that formaldehyde was commonly used as the preservative by domestic vaccine manufacturers. As regards the thimersol, 168 samples from 16 manufacturers were examined and the results showed that no significant difference among manufacturers or between the import and the domestic (p > 0.05). In regard to the results of residual moisture in live vaccines, 200 samples from 17 manufacturers were measured and no significant difference among manufacturers (p > 0.05) was found as well.
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