| Summary |
This experiment was carried out to study toxicity in chickens with different combination ratio of tiamulin (T) and monensin (M). Broilers were divided as follows: Group 1 to 4 were medicated fed with T and Min the ratio of0 : 0, 100 : 50, 200 : 100, and 250 : 120 ppm in feeds for ten days, respectively. T in drinking water: M in feeds were in the ratio of 200 : 200 ppm and 250 : 120 ppm for group 5 and 6. Anorexia, depression, down wings, and drowsiness appeared on days 2 to 4 of administration in treated chicks. On days 5 to 6, eating nothing, leg paralysis, recumbent and drowsiness were prevalent, and severe, Chicks showed gradually recovery from Clinical sigus on days 7 to 9, and became ormal on day 10. All broilers were alive in this experiment except for being sacrificed. No gross lesions were observed. Histopathological examination showed vacuolation in myocardium cell, inflammation cells infiltrated between myofibers, and light to medium level of hemolysis in endocardium. Besides, hyalinisation, granulation of skeletal muscle cell, and a lot of lymphocytes infiltrated in the myofiber were also observed.
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