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An attempt to test the safety of a developing combined vaccine including Bordetlla brohchiseptica and Pasteurella multocida using mice and guinea-pigs, the results indicated that the vaccine tested in this study was safe after inoculation. The results of it's
immunogenecity test on mice showed that the protection index from Bordetella bronchiseptica was more than 100 ( LD50 of experimental group/LD50 of control group was 109.8 /107.0 ). Similar results were found that the survival ratios were 87.5 and O in experimental group and control group, respectively, after challenge by Pasteurella multocida.
A total number of 60 pregnant sows were used for field immunization test. Low antibody titer to Bordetella bronchiseptica of 75% of sows was detectable and other (25%) were detected without antibody titer before vaccination. The geometric mean titer (GMT) of sows of antibody to Bordetella bronchiseptica was 639.05 after vaccination. G M T of suckling Piglets was also high up to 503.32 . This results suggest that the combined vaccine used in this study is safe and it's immunogenecity is evident.
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