| Summary |
The 447 guinea pigs in the National Taiwan University Laboratory Animal Center were transferred to Branch Institute for Animal Drugs Inspection (BIADI) for breeding and supply in February 2001. The guinea pig productivity was under clean conventional management, Of the 1022 born guinea pigs, the 525 postweaning guinea pigs (51.4﹪) were supplied between April and December. Using ELISA for serological monitor, PVM, Reo-3, Sendai, LCMV and SV-5 were detected in June and November, respectively. The result of antibodies detection in June was PVM 100﹪positive (4/4) and Reo-3 100﹪positive(4/4) , nevertheless, which was PVM 33.3﹪positive (3/9)and Reo-3 22.2 ﹪positive(2/9) in November. At necropsy, the interstitial, non-suppurate pneumonia with syncytial cell formation and lymphatic perivascular cuffing was found as the major pathological features, in addition, the fatty change, alopecia and metritis were also observed in some cases. The Bordetella bronchiseptica and Salmonella spp were also inspected as important monitored-pathogens, and the result was negative. Under clean conventional management, 1397 new guinea pigs were produced, in which 810 postweaning guinea pigs (58﹪) were supplied to laboratories in 2002. Serological monitor with ELISA on antibodies against PVM, Reo-3, Sendai, LCMV and SV-5 were performed in June and December 2002. The results showed that 66.7% (6/9) of animals were seropositive to PVM and 66.7﹪(6/9) to Reo-3 in June. Then, in December the positive rate of PVM was 42﹪(5/12) and of Reo-3 was 42﹪(5/12). However, the Sendai, LCMV and SV-5 were negative.
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| Keyword |
guinea pigs, clean conventional, breeding, pneumonia virus of mouse, Reo-3.
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