| Summary |
Five monoclonal antibodies (Mabs) directed against infectious bursa) disease virus strain P3009 were produced and characterized. All five Mabs were found to immunoprecipitate 32 Kd capsid protein, however, none of them neutralized virus infectivity. Antibody competitve binding assays demonstrated the existence of at least three antigenic regions, A, B, and C, of which the regions A and B are overlapping. The binding of Mabs to this protein did not be affected after the viral proteins were denatured, indicating that the binding reaction to 32 Kd protein with all five Mabs prepared in this study was not conformation-dependent.
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