Clinically and pathologically, two lapinized HC vaccine viruses, the LPC-Chinese (LPC) and Chinese (Chinese) strains, caused no abnormal reac-tions in pigs, but induced similar fever responses, the enlargement of lymph nodes (LN), particularly mesentery LN, and hislopathologlcal changes in the
brain, such as neuronal satellitosis, neuronophagla and perivascular cufBngs in rabbits.
Both lapinized HC viruses had a similar viral distribution pattern in rabbits and pigs. Lymphatic tissues were mainly infected with the viruses. The result indicated that these two lapinized HC vaccine viruses had identical patbogenicity and viral distribution In rabbits and pigs. Therefore, it may suggest that these two viruses have the same origin.