AHRI report No.34

Development of Hog Cholera and Swine Erysipelas Bivalent Live Vaccine 

1.     Taiwan Animal Health Research Institute.
2.     Taiwan Domestic Animals Chemical & Pharmaceutical Co., Ltd.
3.     Yunlin hsien Livestock Disease Control Center, Doouluh

The safety of the bivalent vaccine mixed with LPC-PRK strain of hog cholera virus and Coganei strain of swine erysipelas was verified by the facts that side effects and signs of illness did not observed in the mice which were injected with 0.5 ml intraperitoneally and in the pigs which were injected with 100 doses intramuscularly of the vaccine. The potency of the vaccine was proved that all mice injected with 0.1 ml of the vaccine survived after challenge with 100 MLD of virulent erysipelas. According to the current requirements of quality inspection, the pigs vaccinated with 1 / 100 and 1 / 500 doses were challenged with 104 MLD of the virulent ALD strain of hog cholera virus 10 days after vaccination. Febrile reaction was noticed only in one out of four pigs vaccinated with 1 / 500 dose of the vaccine. On the other hand, 3 control pigs developed signs of illness and died after challenge. A field trial was conducted at 4 pig farms in YunLin prefecture. Totally, 1200 pigs with 6 weeks of age were vaccinated and 100 pigs served as the control. All of the vaccinated pigs were normal and healthy during the period of trial. 

hog cholera , erysipelas , bivalent vaccine