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Propagative ability of the gE and TK double gene-deleted R23 strain constructed from local isolate and natural gE gene-deleted Bartha strain of pseudorabies virus both in PK cell line was satisfied. Immune protective efficacy of these two inactivated vaccines in rabbits was comparable with that of S-38 field strain and imported gE gene-deleted N and SB vaccines. Protective dosage in rabbits induced by all of them could pass the test of national drug assay.
The neutralizing antibodies of secondary SPF pigs with 5~ 7 weeks of age eilicited by the local gene-deleted R23 inactivated vaccine were slightly lower then those by other vaccines. However, it protected the pigs as good as the other vaccines when evaluated by mean fever and virus shedding days points of view.
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