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Summary
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To investigate the potency of a trivalent bacterin containing serotypes 1,2 and 6 against Riemerella anatipestifer infection, a bacterin was manufactured on a large scale and tested in the laboratory and on waterfowl farms. The Beherens-Karber method was used to evaluate the protection index based on LD50 from vaccinated and control animals. The results showed that all of the protection indices achieved the national standards of animal drug inspection. This bacterin was found to provide protection against experimental homologous serotype challenges. We performed efficacy tests as well as detection of sera antibody in mice, the results indicating that vaccinated mice exhibit a strong response to immunogens against Riemerella anatipestifer.
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Keyword
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Riemerella anatipestifer, inactivated bacterin, potency test, field trial, mouse model
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