| Reportno. |
AHRI report No.41
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| Topic |
The pharmacokinetics of aquatic antimicrobials in cobia (1)
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| Department |
1.Animal Health Research Institute, Council of agriculture, Executive Yuan
2.National Taiwan University, Department of Veterinary Medicine
3.Fishery Research Institute, Biotechnology Division |
| Author |
Tu C*1, Chang SK 2, Chang CF 3, Huang SM 1, Song MJ 1 Kuo HJ 2, Yang GH 3, Cherng JC 1, Chang WM 1 |
| Summary |
The purpose of this study was to evaluate the possible residue time of amoxicillin and ampicillin in tissues of cobia Rachycentron canadum after a single oral dose and to help
confirm withdrawal period of those drugs. The author used hard stomach tube for drug administration at each study. This method significantly increases the accuracy of drug
administration and decreases the stress of experimental fish. The authors also modified other researches’ analytic methods, such as decrease of extraction time, decrease of amount of waste organic solvent, and changes of pH in mobile phase. All mentioned improvements made the analysis more easily to operate than before. There is no maximum residue levels can be compared directly at present time. Our HPLC results indicated that the muscle and blood concentration for ampicillin and amoxicillin were lower than or close to 0.01μg/ml (maximal residue allowed for animal drugs by Department of Health) 48 hours after a single oral administration.
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| Keyword |
Cobia Rachycentron canadum, amoxicillin, ampicillin, withdrawal period
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