in orde assay cartedox, olaquidox, fuiaaDlidone nitrofurane and nitrovinin feel siruutans>usly, the conpletely reseluti clixomatogran might be oboinel using C8 silica gel column (5 urn, 25cm) under the condition of solvent gradient gogran. The gOgrarn was linear gradient of 5% acetonitrile per minute mainly. The relation ccefficienis 0 of calibration curves 015 feel additives were above 0.99). The relative
standard deviations of these drugs were below 3.0%, only Sppra NW was somewhat large (6.7%). The merlica feels were extracJ by pretreatg with water, extrwtel with 95% dimethyl fornamide overnight at rcon tenperature, cleaned upon a column of alumina oxide. Paovex’ies of carbadox, olarpiindox, fuxa2oridone, nitrofrazone and nitrovin from low level medicatl feel were 102.0,94497.4,110.6 and 660%, xespeDtively and high level were 114.0,99.1,97.3, lO).9 and 62.7%, respeDtively.