Brief introduction of pyrogen test and Animal injection bacterial endotoxin test evaluation

Chen Yu-Hsien

Abstract

The goal of the project is to establish a national animal drug testing laboratory to perform bacterial endotoxin testing and to conduct endotoxin investigations on animal injections. The results can be used as a reference for the authorities to revised test standards in the future. Looking forward to meet the international injection quality standards and decrease the quality gap between animal and human drugs, in the other hand to enhance domestic animal drugs manufacturers' self-requirements for their own products. Via large amount training and practice, we completed every step requirements for bacterial endotoxin test: CSE serial dilution, labeled lysate sensitivity test, sample dilution inhibition/enhancement test and sample limit test. In the project, a number of 35 samples of animal injection products were executed inhibition/enhancement tests and 51 samples (lots) executed limited test using two brands of commercial BHT gel-clot reagents. Most of products could pass the pharmacopoeia specification.

Investigation on Important Aquatic Animal Virus Diseases 2018

Chien Tu

Abstract

A total of 5602 cases were submitted to Biology Division. Among those, 330 cases of viral infections were detected. The main fish virus diseases included 128 cases of iridovirus, 43 cases of koi herpesvirus, 30 cases of nervous necrosis virus, 12 cases of aquabirnavirus, 9 cases of Japanese eel endothelial cells-infecting virus and 3 cases of carp edema virus. The main shrimp virus diseases included 61 cases of white spot syndrome virus, 33 cases of infectious hypodermal and hematopoietic virus and one case of yellow head virus. The principal infections in fish and shrimp were caused by irodvirus and white spot syndrome virus, individually.