Introduction to the Current Development and Testing Methods of Chicken Coccidiosis Vaccine

Yun-Ping Chang

Abstract

Coccidiosis has long been one of the most troubling diseases for poultry farmers. The clinical symptoms are related to the virulence of the pathogen and the dosage of infection, ranging from no obvious symptoms to poor growth, low feed conversion rates, soft stools, mucous diarrhea, bloody diarrhea, and even death. Different species of coccidia infect various locations in the intestinal tract and cause different lesions. Chickens that recover gain resistance to reinfection, but this resistance only applies to the same species of coccidia and does not provide cross-immunity against different strains. For a long time, poultry farmers have added antibiotic medications to feed as an important strategy to prevent and control coccidiosis. The application of coccidiosis vaccines is an emerging control strategy. This seminar provides an overview of the current development of live coccidiosis vaccines for chickens and introduces methods for vaccine testing.

Study in South Korea on the Batch Inspection System and Testing Techniques for Veterinary Vaccines

I-Ting Ko

Abstract

The Animal and Plant Quarantine Agency (APQA) of Korea is responsible for animal and plant quarantine and managing veterinary drugs. It has also implemented a batch-by-batch inspection system for veterinary vaccines, including the national lot release (NLR) and the NLR assay exemption (NLRAE) system. Under this system, vaccine products that pass ten consecutive batch inspections are exempted from further batch-by-batch testing, allowing manufacturers to conduct self-inspections, while the government ensures product quality through market sampling. This model significantly reduces the government's burden while placing higher demands on manufacturers for self-regulation.

Korea plans to introduce the seed-lot system (SLS) in 2025, requiring vaccine manufacturers to submit detailed technical data on vaccine seeds and cell banks to ensure product quality and consistency. This system is designed to be implemented in phases over seven years, to reduce final product quality control testing, enhance international competitiveness, and minimize the use of laboratory animals.

Korean veterinary vaccine management system, which progressively reduces batch-by-batch inspections while strengthening manufacturers’ self-regulation, serves as a valuable reference for our country. However, the impact of the upcoming seed-lot system on the industry remains to be observed. This training program has established a communication channel with APQA, and future developments in its policies will continue to be monitored as a reference for the reform of our domestic veterinary vaccine inspection system.