Establishment of a method to evaluate the safety and efficacy of the E2-subunit vaccine against classical swine fever in pregnant sows

Jen-Huan Tsai

Abstract

Classical swine fever is a highly contagious septicemia caused by the infection of classical swine fever virus, which is an RNA virus belonging to the genus Pestivirus of the family Flaviviridae. Due to transplacental transmission of the virus, vaccine efficacy evaluations must be conducted both in pregnant sows and piglet so as to ensure adequate protection. We therefore established a vaccine challenge trial in pregnant sows as a method to assess the safety and efficacy of the E2-subunit vaccine.

Quality Control Testing of Biologics from 2020-2021

Cheng-chu Hsieh

Abstract

In 1988, the Animal Health Research Institute (AHRI) established a pharmaceutical factory that complied with international GMP standard requirements. The main tasks of the biological products division are the production, development, storage and supply of vaccines and diagnostic reagents. AHRI currently possesses 21 manufacturing licenses for various biological animal products including a Newcastle disease hemaggluutination antigen, a pullorum disease antigen, a bovine ephemeral fever inactivated vaccine, a hog cholera tissue culture live vaccine, a waterfowl parvovirus live vaccine, a goat pox attenuated live vaccine, and Riemerella anatipestifer (RA) inactivated trivalent bacterins (serotpye 1, 2 and 6). An analysis of data from 2020-2021 showed that more than 10 different batches of biological preparations are manufactured each year. Each batch was certified for quality control and national inspection, thereby safely ensuring domestic epidemic prevention and diagnosis.