C. Chen 1FC.C. Lu lFLP. Chan 1F3.S. Lai lflG. Chang lFS.T. Lin lFK.T. Chou 2aFC.3. Li 2FTD. Yan2FS.J. Wu2FK.N. Chen
An attempt to test the safety of a developing combined vaccine including Bordetila bronchiseptica and Pasteurella multocida using mice and guineapgis. the results indicated that the vaccine tested in this study was safe after inoculation. The results of ifs immunogenecitv test on mice showed that the protection index from Bordetella bronchiseptica was more than 100 (LDSO of experimental group LDSO of control group was 109.8l0’7.0). Similar results were found that the survival ratios were 87.5 and in experimental group and control group, respectively, after challenge by Pasteurella multocida.
A total number of 60 pregnant sows were sused for field immunization test. Low antibody titer to Bordetellabronchiseptica of 75°o of sows was detectable and other (25%) were detected without antibody titer before vaccination. The geometric mean titer (GMT) of sows of antibody to Bordetella bronchiseptica was 639.05 after vaccination. GMT of sucking Piglets was also high up to 50332. This results suggest that the combined vaccine used in this study is safe and ifs immunogenecity is evident