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Study on the Co-infection of Porcine Reproductive and Respiratory Syndrome Virus...  

Update Date: [2013-11-14]
No.:47

Reporton.
AHRI report No.47
Topic
Study on the Co-infection of Porcine Reproductive and Respiratory Syndrome Virus and Porcine Circovirus Type 2 in the Commercial Pig Farms
Department
Animal Heath Research Institute, Council of Agriculture, Executive Yuan
Author
YL Huang, MC Deng, CY Chang
Summary
Porcine reproductive and respiratory syndrome virus (PRRSV) and porcine circovirus type 2 (PCV2) are the major causes of porcine respiratory disease complex (PRDC) and lead high mortality in nursery-to-finish pig herds. In order to study the susceptible age of PCV2 and PRRSV and pathogenesis of PCV2- and PRRSV-induced PRDC, we collected serum samples of various ages from 5 herds to assay susceptible age of PCV2 and PRRSV and collected 50 lung tissues of PRDC to assay the cytokine regulation. The titer of anti-PRRSV neutralizing antibody was lowest between 6 and 8 week-olds and was significantly raised after 14 week-olds. On the contrary, the morbidity of PRRSV reached peak at 8 week-olds and then gradually decreased over time. The titer of PCV2 ORF2 antibody in 3 herds without PCV2 vaccination was gradually decrease over time, however, the morbidity of PCV2 in various age among 3 herds was significantly different and was positive correlation with the mortality in nursery-to-finish pig herds. In addition, more than 80% PRDC cases were caused by PCV2 and/or PRRSV. These results indicated that PCV2 and PRRSV infections are also the major problem in pig herds of Taiwan.
Keyword
Porcine reproductive and respiratory syndrome virus, porcine circovirus type 2, porcine respiratory disease complex