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Publication Review:Pathogenesis of Transmissible Spongiform Encephalopathies in ...  

Update Date: [2013-11-13]

NO.: 37

AHRI report No.37


Review:Pathogenesis of Transmissible Spongiform Encephalopathies in Molecular Biology Aspects



Animal Health Research hstitxt Council of Agriculture

Author Shu-Hwae LEE, Kuo-Hui CHAN Ming-Hwa JONG, Shih-Yuh LIN

SUMMARY Anthrax, the worldwide disease caused by the spfonniag Bacillus anthracis, now has kecome the fcc-us again since several fal cases of human were idenhfied in America. Warrn-bkcdal animals axe generally susceptible to the agent. Shecp and cattle axe er&ularly sensitive. Anthrax is generally considered a soilbcxrne infection and does not commonly sptad by animal to animal. Anthrax is usually dassified as inhalation, gastrointstinal and cutaneous forms by the entry portals of infection and rex’gnid as pharyngea], intstinal and septicernic types by the clinical fh[hu1 signs, Bacillus anthracis secrets two toxins, that axe cornjnsed of protective antigen (PA), lethal factor (LF) and edema factor (EF). The PA plus IF elicit death of animal, whereas PA plus EF prcdwe edema in the sian. Anthrax should bo sus when the carcass is neczojasied and ratients show exnsive edema and unclotting Mccxl. Similar signs were noticed in a dead racing horse, which was submited to the National listitae fo’r Animal Health for necxoy fromahorse park in Novemirer 1999. Dark-hown nasal discharge and exersive edematous swelling in body surface were oMerved.



Spo’ngiforin protective antigenlethal factor; edema factor.