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Publication Chromosome Aberration Test of Feed Additives in Chinese Hamster CHO-...  

Update Date: [2013-11-11]

NO.: 28
 
Reportno.

AHRI report No.28

Topic

Chromosome Aberration Test of Feed Additives in Chinese Hamster CHO-Kl Cell

Department

Taiwan Animal Health Research Institute

Author S.C. LeeFS.Y. LinFS.Y. Chiu
Summary

Experiments were conducted to investigate the residue ofkitasamvcin (100 ppm) and tvlosin (110 ppm) fed to pigs, and kitasamycin (11 ppm) and tylosin (1100 ppm)fed to broilers. The feeding experiments lasted for 1 month. Pigs or broilers were slaughtered after one to six or eight days of withdrawal period. Tissues were sampled and undergone extraction condensation and then assayed by microbiological cylinder plate methods. In the experiment ofkitasamycin fed to pigs, there were 0.16, 0.48 and 0.40 meg g of drug residue in meat, liver and kidney, respectively on day of withdrawal period, 0.16 and 0.11 mcgg residued in liver and kidney on day 1. When fed to broilers: 0.1—0.4 meg g (ml) ofkitasamycin residued in meat tissue on day 2 of withdrawal, 0.1 meg g ofkitasamycin residued liver and days. No drug activity could be detected from meat and tissues on day 8 of withdrawal. In the experiment oftylosin fed to pigs, liver and kidney had 030 and 0.26 meg g of tylosin on day 0. In the case of broilers, mea , liver and zizzard had 0.1,0.6 and 0.1 mcgg oftylosin on day 3 ofwithdrawalperiod; liver had 0.2 mcgg oftylosin on day 4. No drug activity could be detected from meat and tissues on day 6 of withdrawal.

Keyword

KitasamycinflylosinFChromosome Aberration Test