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Publication The pharmacokinetics of erythromycin in cobia  

Update Date: [2013-11-14]

NO.: 42
 
Reportno. AHRI report No.42
Topic The pharmacokinetics of erythromycin in cobia
Department Animal Health Research Institute, Council of Agriculture, Executive Yuan1, Veterinary Medicine Department, National Taiwan University2 and Tungkang Technology Research Center, Fisheries Research Institute, Council of Agriculture, Executive Yuan3
Author Tu C1 * , Cherng JC1, Chang SK2, Chand CF3, Chiou RY1, Huang SM1 and Chang WM1
Summary
The erythromycin concentration in the serum of cobia Rachycentron canadum were monitored following oral administration of erythromycin once daily, or once every three days. Our results showed that two-peak erythromycin concentrations (46.7--95.5 μg/mL) occurred at 0.5-1 hr and 18-24 hr post oral dosing, respectively. The two-peak pattern of erythromycin concentration in serum, indicating an enterohepatic circulation, was found in both once-a-day and once every three days regimens, which reached the highest concentration at 0.5-1 hr, and retained its highest concentration longer at 18-24 hr. The serum erythromycin concentration decreased to 0.6--1.8 μg/ mL at 216 hr after oral adminstration. Due to the lack of antibiotic residue standards for erythromycin in fish in the Guidelines for Animal Drug Residues by Department of Health in Taiwan , we can not compare our data to that of the present regulation. If the farmers would follow the withdrawal time of 14--30 days for erythromycin recommended by the Aquatic Animal Drugs Guidelines, the antibiotic residues in cobia should be less than 0.3 μg/g, which was equal to the maximal residue of erythromycin in pig and cow tissues allowing for human consumption in the Guidelines for Animal Drug Residues in Taiwan . 
Keyword cobia Rachycentron canadum, erythromycin, withdrawal period, hard stomach tube