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Seminar 774  
Seminar:  774
CH Pan CS. Hwang
Non-human Primates Used for Biomedical Research
The genetic similarities of non-human primates to humans have made them ideal candidates for studying human genetics in medical and biomedical research around the world. In particular, the species of Macaca mulatta (rhesus monkey) has been favored for such purposes. However, since macaques became protected animals in most parts of the world in recent years, many biomedical labs have been facing the challenge of finding suitable alternatives for experiments. In Taiwan, M. cyclopis is a native species and usually lives in grassland and mountains. These monkeys are found to be most similar to rhesus monkeys in their genetic make-up, making them a fitting alternative for Taiwan’s biomedical research. However, as research involving monkeys in Taiwan has been fairly new, necessary facilities and techniques are not well established. In light of this, in 2003 our institute set up facilities for such research which include 30 monkeys and a laboratory for surgical treatment to support vaccine research. In addition, we have completed a database of M. cyclopis containing information of its basic physiology, genetics and infectious diseases. With these resources we were able to study, in collaboration with Yang Ming University, Taiwan University Medical School, National Defense Medical University, Tsing Hua University, and National Health Research Institute, the spinal cord damage, xenotransplantation, tooth bone reconstruction, enterovirus 71 vaccine, and Dengue fever vaccine in 2008.
Yen-Lin Lee
Development of bovine ephemeral fever live vaccine based on YHL strain
Bovine ephemeral fever (BEF) is an arthropod-borne viral disease most commonly found in tropical and subtropical zones. Since its first occurrence in 1967 in Taiwan, it has been breaking out regularly in every 3-6 years among the cattle population. To counter that, a vaccination program with inactivated virus has been conducted with two shots as the basic vaccination in calves, one at birth while the other one few weeks later, followed by regular inoculation twice a year thereafter. Despite this precaution, these shots can only induce humoral immunity and do not always prevent unnecessary losses. In light of this, we will be using the Japanese BEF live vaccine virus strain (YHL) to develop live vaccine which can be used as the basic vaccination to enhance the immune responses of calves. Several evaluations of the live vaccine will be carried out in the next 3 years, including safety tests, efficacy tests, virus regression tests, storage period tests, and field trials, among others. We hope to supply the live vaccine with good immunogenicity that could prevent the disease effectively.